Did you ever hear someone being described as being loopy (like whacko, nuts, loco, or acting stupid)? Well, the term comes from olden days of yore (pre-pharmaceutical days).
In the good ole ' days before aspirin and vicodin, the doctor would sedate you with compressed tablets of lupulin before they yanked your teeth out , operated, or set upon you with leeches. The lupulin was the yellow pollen stuff found in Hop plant cones! Patients under the influence of luplin ingestion were described as "loopy".
Lupulin is found in Hops cones.(And did I mention Hops are closely related to marijuana?) The hop cones are used in brewing beer. Heavy beer drinking leads to being "loopy". But hey, it's not the beer drinkers fault- it's the lupulin!
Which raises the question- What is the hard liquor drinker's excuse?
And now you know . . .